I have used Minecraft-style cubed characters as my colonists, as they're easy to model, texture and animate, but that's really where the Minecraft similarities end... more or less.
Here's a picture of 19 year old Ben, pondering about the limestone he's standing on, who also looks remarkably like a thin Peter Griffen (freakin' sweet!).
First thing to do in the new year is add a way to make "rooms" or "areas", so you can designate a building as a house, space-tavern, graveyard etc. The colonists will then know what to use it for. Non-marked areas can then be used for farming, mining etc.
So much still to do and I'm enjoying it!